TCART Articles

Below, find selected research articles from TCART and Dr. Casper's University laboratory. A complete listing of research papers is available by searching in Pubmed for “Casper RF”.

Mitwally MFM, Casper RF. (2002) Effect of in-vivo GnRH agonist and GnRH antagonist suppression on progesterone production by human granulosa lutein cells. Journal of Assisted Reproduction and Genetics, 19(8):384-389.
Mitwally MF, Gotlieb L, Casper RF. (2002) Prevention of bone loss and hypoestrogenic symptoms by estrogen and interrupted progestogen addback in long-term GnRH agonist down-regulated patients with endometriosis and premenstrual syndrome. Menopause, 9(4):236-241.
Fisher SA, Reid RL, VanVugt DA, Casper RF. (2002) A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor, Letrozole, on ovulatory function in normal women. Fertility and Sterility, 78(2):280- 285.
Ben Chetrit A, Antenos M, Jurisicova A, Pasyk E, Chitayat D, Foskett K, Casper RF. (2002) Expression and function of Cystic fibrosis transmembrane conductance regulator during early human embryo development. Molecular Human Reproduction, 8(8):758-764.
Jurisicova A, Antenos M, Varmuza S, Tilly J, Casper RF. (2003) Expression of apoptosis-related genes during human preimplantation embryo development: Potential roles for the Harakiri gene product and Caspase-3 blastomere fragmentation. Molecular Human Reproduction, 9(3):133-141.
Mitwally MF, Casper RF. (2003) Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility. Human Reproduction, 18(8):1588-1597.
Fasciani A, Bocci G, Xu J, Greenblatt E, Leyland N, Casper RF. (2003) Threedimensional in vitro culture of endometrial explants mimics the early stages of endometriosis. Fertility and Sterility, 80(5):1137-1143.
Casper RF. (2003) Letrozole: Ovulation or superovulation? Fertility and Sterility, 80(6):1335-1337.
Acton BM, Jurisicova A, Jurisica I, Casper RF. (2004) Alternations in mitochondrial membrane potential during preimplantation stages of murine and human embryo development. Molecular Human Reproduction, 10 (1):23-32.
Mitwally MF, Casper RF. (2004) Aromatase inhibitors in ovulation induction. Seminars in Reproductive Medicine, 22(1):67-78.
Esfandirai N, Claessens EA, O’Brien A, Gotlieb L, Casper RF. (2004). Gestational carrier is an optimal method for pregnancy in patients with vaginal agenesis (Rokitansky syndrome). International Journal of Fertility and Women’s Medicine, 49(2):79-82.
Mitwally MF, Casper RF. (2004) Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation. Journal of the Society for Gynecologic Investigation, 11(6):406-415.
Mitwally MF, Abdel-Razeq S, Casper RF. (2004) Human chorionic gonadotropin administration is associated with high pregnancy rates during ovarian stimulation and timed intercourse or intrauterine insemination. Reproductive Biology and Endocrinology, 2:55.
Rogers I, Casper RF. (2004) Umbilical cord blood stem cells. Best Practices and Research Clinical Obstetrics Gynaecology, 18(6):406-415
Mitwally MF, Casper RF. (2005) Single dose administration of an aromatase inhibitor for ovarian stimulation. Fertility and Sterility, 83(1):229-231.
Mitwally MF, Biljan MM, Casper RF. (2005) Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation. American Journal of Obstetrics and Gynecology, 192:381-386.
Mitwally MF, Casper RF, Diamond MP. (2005) Oestrogen-selective modulation of FSH and LH secretion by pituitary gland. British Journal of Cancer, 92(2):416-417.
Esfandiari N, Gotlieb L, Casper RF (2005). Live birth of healthy triplets after in vitro fertilization and embryo transfer in an acromegalic woman with elevated growth hormone. Fertility and Sterility, 83(4):1041.
Kayumov L, Casper RF, Hawa RJ, Perelman B, Chung SA, Sokalsky S, Shapiro CM. (2005) Blocking low-wavelength light prevents nocturnal melatonin suppression with no adverse effect on performance during simulated shift work. Journal of Clinical Endocrinology & Metabolism, 90(5):2755-2761.
Esfandiari N, Javed MH, Gotlieb L, Casper RF. (2005) Complete failed fertilization after intracytoplasmic sperm injection –analysis of 10 years’ data. International Journal of Fertility and Women’s Medicine, 50(4):187-192
Casper RF. (2005) Are recombinant gonadotrophins safer, purer and more effective than urinary gonadotrophins? Reproductive Biomedicine Online Journal, 11(5):539-540.
Esfandiari N, Ryan EAJ, Gotlieb L, Casper RF. (2005) Successful pregnancy following transfer of embryos from oocytes with abnormal zona pellucida and cytoplasm morphology. Case Report. Reproductive Biomedicine Online Journal, 11(5):620-623
Madlambayan GJ, Rogers I, Kirouac DC, Yamanaka N, Mazurier F, Doedens M, Casper RF, Dick JE, Zandstra PW. (2005) Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Experimental Hematology, 33(10):1229-1239. Erratum in: Exp Hematol. 2006 Jan; 34(1):122.
Esfandiari N, Gotlieb L, Casper RF. (2006) Seminal hyperviscosity is associated with poor outcome of controlled ovarian stimulation and intrauterine insemination: a prospective study. International Journal Fertility 51(1):21-27.
Esfandiari N, Nazemian Z, Casper RF. (2006) Human oocyte banking; Clinical applications and limitations. International Journal of Endocrinology and Metabolism. 4:216-223
Tulandi T, Martin J, Al-Fadhli R, Kabli N, Forman R, Hitkari J, Librach C, Greenblatt E, Casper RF. (2006) Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertility and Sterility 85(6):1761-1765.
Bedaiwy MA, Casper RF. (2006) Treatment with leuprolide acetate and hormonal add-back for up to 10 years in stage IV endometriosis patients with chronic pelvic pain. Fertility and Sterility, 86(1):220-222.
Bedaiwy MA, Falcone T, Mascha EJ, Casper RF. (2006) Genetic polymorphism in the fibrinolytic system is associated with endometriosis: a potential etiologic mechanism. Obstetrics & Gynecology, 108(1):162-168.
Bedaiwy MA, Forman R, Mousa NA, Inany HG, Casper RF. (2006) Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation. Human Reproduction. 21(11):2838-2844.
Casper RF. (2006) Is paroxetine an effective treatment for hot flashes? Nature Clinical Practice Endocrinology & Metabolism, 2(5):250-251.
Esfandiari N, Burjag H, Gotlieb L, Casper RF. (2006) Brown oocytes: Implications for assisted reproductive technology. Fertility and Sterility, 86(5):1522-1525.
Mitwally MF, Casper RF. (2006) Potential of aromatase inhibitors for ovulation and superovulation induction in infertile women. Drugs, 66(17):2149-2160.
Perez GI, Acton BM, Jurisicova A, Perkins GA, White A, Brown J, Trbovich AM, Kim MR, Fissore R, Xu J, Ahmadu A, D’Estaing SG, Li H, Kagawa W, Kurumizaka H, Yokoyama S, Okada H, Mak TW, Ellisman MH, Casper RF, Tilly JL. (2007) Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure. Cell Death & Differentiation, 14(3):524-533.
Esfandiari N., Khazaei M, Ai J, Bielecki R, Gotlieb L, Casper RF. (2007) Effect of a statin on an in vitro model of endometriosis. Fertility and Sterility, 87(2):257-262.
Esfandiari N, Ai, J, Nazemian Z, Javed MH, Gotlieb L, Casper RF. (2007) Expression of glycodeline and cyclooxygenase-2 in human endometrial tissue following threedimensional culture. American Journal of Reproductive Immunology, 57(1):49-54.
Bedaiwy MA, Mousa NA, Esfandiari N, Forman R, Casper RF. (2007) Follicular phase dynamics with aromatase inhibitor and follicle stimulating hormone cotreatment. Journal of Clinical Endocrinology & Metabolism, 92(3):825-833.
Quinn CE, Ryan E, Claessens EA, Greenblatt E, Hawrylyshyn P, Cruickshank B, Hannam T, Dunk C, Casper RF. (2007) The presence of pinopodes in the human endometrium does not delineate the implantation window. Fertility and Sterility, 87(5):1015-1021.
Quinn CE, Detmar J, Casper RF. Pinopodes are Present in Lif Null and Hoxa10 Null Mice. Fertility and Sterility, 2007.88(4) (Suppl 1):1021-1028.
Rogers I, Yamanaka N, Bielecki R, Wong CJ, Chua S, Yean S, Casper RF. (2007) Identification and analysis of in vitro cultured CD45-positive cells capable of multilineage differentiation. Experimental Cell Research, 313(9):1839-1852.
Mousa NA, Bedaiwy MA, Casper RF. (2007) Aromatase inhibitors in the treatment of severe endometriosis. Obstetrics & Gynecology. 109(6):1421-1423.
Acton BM, Lai I, Shang X, Jurisicova A, Casper RF. (2007) Neutral mitochondral heteroplasmy alters physiological function in mice. Biol Reprod. 77(3):569-576.
Casper RF. (2007) Aromatase inhibition in ovarian stimulation. J Steroid Biochem Mol Biol. 106(1-5):71-5.
Forman R, Gill S, Moretti M, Tulandi T, Koren G, Casper RF. (2007) MOTHERISK ROUND: Fetal Safety of Letrozole and Clomiphene Citrate for Ovulation Induction. Obstetrics & Gynecology, Can 29(8):668-71.
Forman R, Gill S, Moretti M, Tulandi T, Koren G, Casper RF. (2007) Fetal safety of letrozole and clomiphene citrate for ovulation induction. Journal of Obstetrics & Gynecology Canada, 29(8):668-671.
Jurisicova A, Taniuchi A, Li H, Shang Y, Antenos M, Detmar J, Xu J, Matikainen T, Hernandez AB, Nunez G, Casper RF. (2007). Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. Journal of Clinical Investigation, 117(12):3971-8.
Esfandiari N, Nazemian Z, Casper RF. (2008) Three-dimensional culture of endometrial cells; an in vitro model of endometriosis. American Journal of Reproductive Immunology, 60(4):283-289(7)
Esfandiari N, Coogan-Prewer J, Gotlieb L, Casper R.F. (2008) Successful pregnancy following double frozen embryo transfer in a patient with repeated implantation failure. Fertility and Sterility, 90(4):1199.e13-1199.e15.
Bentov Y, Casper RF. (2008) Sex hormone receptors and testosterone in postmenopausal women. Menopause - The Journal of The North American Menopause Society, 15(2):210-211.
Detmar J, Rennie MY, Whiteley KJ, Qu D, Taniuchi Y, Shang X, Casper RF, Adamson SL, Sled JG, Jurisicova A. (2008) Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR – dependent changes in cell death. American Journal of Physiology – Endocrinology and Metabolism, 295(2):E519-530.
Esfandiari N, Burjaq H, Gotlieb L, Casper RF. (2008) Seminal hyperviscosity is associated with poor outcome of in vitro fertilization and embryo transfer: A prospective study. Fertility and Sterility, 90(5):1739-43.
Esfandiari N, Claessens EA, Burjaq H, Gotlieb L, Casper RF. (2008) Ongoing Twin Pregnancy after rescue intracytoplasmic sperm injection of unfertilized abnormal oocytes. Fertility and Sterility, 90(1):199.e5-199.e7.
Mousa NA , Crystal P, Wolfman WL, Bedaiwy MA, Casper RF. (2008) Aromatase inhibitors and mammographic breast density in postmenopausal women receiving hormone replacement therapy. Menopause, 15(5):875-884.
Esfandiari N, Claessens EA, Gotlieb L, Casper RF (2008). Don’t judge a book by its cover; a quintuplet pregnancy following transfer of five poor-quality embryos. Fertility and Sterility, 90(1):199.e5-7.
Quinn CE, Folkard C, Detmal J, Casper RF. (2008) Enhanced endocytotic and transcytotic activity in the rat endometrium prior to embryo implantation. Journal of Molecular Histology, 39(4):409-415
Esfandiari N, Nazemian Z, Casper RF. (2008). Three-dimensional culture of endometrial cells: An in vitro model of endometriosis. American Journal of Reproductive Immunology, 60(4):283-289.
Rahman SA, Kollara A, Brown TJ, Casper RF. (2008) Selectively filtering short wavelengths attenuates the disruptive effects of nocturnal light on endocrine and molecular circadian phase markers in rats. Endocrinology. 149(12):6125-35.
Rogers IM, Yamanaka N, Casper RF. (2008) A simplified procedure for hematopoietic stem cell amplification using a serum-free, feeder cell-free culture system. Biology of Blood and Marrow Transplantation, 14(8):927-37.
Chua SJ, Bielecki R, Wong CJ, Yamanaka N, Rogers IM, Casper RF. (2009) Neural progenitors, neurons and oligodendrocytes from human umbilical cord blood cells in a serum-free, feeder-free cell culture. Biochemical and Biophysical Research Communications, [Feb 6]; 379(2):217-221.
Bedaiwy MA, Mousa NA, Casper RF. (2009) Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists. Fertility and Sterility, [Apr]; 91(4 Suppl):1574-1577.
Khazaei M, Montaseri A, Casper RF (2009). Letrozole stimulates the growth of human endometrial explants cultured in three-dimensional fibrin matrix. Fertility and Sterility, [May]; 91(5 Suppl):2172-2176.
Bentov Y, Brown TJ, Akbari MR, Royer R, Risch H, Rosen B, McLaughlin J, Sun P, Zhang S, Narod SA, Casper RF. (2009) Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer. PLoS One, [June 15]; 4(6):e5918.
Bedaiwy MA, Shokry M, Mousa N, Claessens A, Esfandiari N, Gotlieb L, Casper RF. (2009) Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. Fertility and Sterility, [June]; 91(6):2501-2507.
Casper RF. (2009) Letrozole versus Clomiphene Citrate: Which is better for ovulation induction? Fertility and Sterility, [Sept 9]; 2(3):858-859.
Bedaiwy MA, Mousa NA, Casper RF. (2009) Aromatase inhibitors: Potential reproductive implications. Journal of Minimally Invasive Gynecology, [Sept-Oct]; 16(5):533-539
Giuffrida D, Rogers IM, Nagy A, Calogero AE, Brown TJ, Casper RF. (2009) Human embryonic stem cells secrete soluble factors that inhibit cancer cell growth. Cell Proliferation, [Dec]; 42(6):788-798.
Javed M, Esfandiari N, Casper RF. (2009). Failed fertilization after clinical intracytoplasmic sperm injection. Reproductive Bio Medicine Online, [Jan] 20(1):56-67.
Mousa, NA, Jebrail MJ, Yang H.,. Abdelgawad M, Metalnikov P., Chen J, Wheeler AR.,. Casper RF, 2009. Droplet-scale estrogen assays in breast tissue, blood, and serum. Science Translational Medicine, [Oct.], 1(1):1ra2.
Bentov Y, Esfandiari N, Burstein E, Casper RF. (2010) The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertility and Sterility, [Jan]; 93(1):272-275.
Perumalsamy, A, Fernandes, R, Lai, I, Detmar, J, Varmuza, S, Casper, RF, Jurisicova, A. (2010) Developmental consequences of alternative Bcl-x splicing during preimplantation embryo development. FEBS Journal, [Feb. 3]; 277:1219- 1233.
Bentov, Y, Esfandiari, N, Goktur, A, Burstein, E, Fainaru, O, Casper, RF. (2010) An ongoing pregnancy from two waves of follicles developing during long follicular phase of the same cycle. Fertility and Sterility, [Feb 4]; [Epub ahead of print: PMID: 20138269].
Fainaru, O., Amsalem, H, Bentov, Y, Esfandiari, N, Casper, RF. (2010) CD56(bright)CD16(-) natural killer cells accumulate in ovarian follicular fluid of patients undergoing in vitro fertilization. Fertility and Sterility, [Feb 9]; [Epub ahead of print: PMID: 20149364]