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University
of Toronto
TCART is affiliated with University
of Toronto, an educational institution acclaimed as Canada's
leader in research. Macleans Magazine consistently ranks the
University of Toronto as one of Canada's top research-intensive
university.
TCART has
immediate access to all new research findings of the Division
of Reproductive Sciences, Department
of Obstetrics and Gynecology at the University of Toronto,
and participates in research protocols approved by the University
of Toronto Committee for Research on Human Subjects.
TCART Staff Contributing to Technology
Dr. Robert F. Casper, head of
the TCART medical staff, has been very active in reproductive endocrine
and infertility research over the last 25 years, with more than
250 research publications in peer-reviewed journals and/or medical
text books. Dr Casper is a past president of the Canadian Fertility
and Andrology Society and is a member of the editorial board of
several leading fertility research journals.
Together with Dr. Casper, several
members of the TCART medical staff have contributed to the rapidly-advancing
field of reproductive technology. At TCART, we have pioneered several
innovative techniques or treatments. For example, we developed testing
for DNA fragmentation in sperm, which is now routinely performed
at MSH. We also pioneered a method for selecting viable sperm for
ICSI from samples with no sperm motility. Dr Casper and his research
team were the first to use aromatase inhibitors for ovulation induction
as a replacement for clomiphene (Clomid, Serophene) in women with
side effects to the older drugs. We demonstrated the success of
a slow cooling technique for oocyte freezing at TCART, resulting
in the first pregnancy (twins) from this procedure in Canada. More
recently, we have used an in vitro model of endometriosis that we
developed to find new treatments for this condition and to answer
the question of why some women get endometriosis while others don't.
As a result of this research, we have determined the genetic basis
of endometriosis and a potential gene test to detect young girls
at risk of developing endometriosis.
What Does This Mean for TCART Patients?
The TCART medical staff have
the ability to use the latest information and techniques developed
from the research conducted at the University of Toronto and the
surrounding Toronto teaching hospitals in helping you to achieve
your fertility goals.
Selected
Research Articles from TCART and Dr. Casper's University Laboratory
Complete listing of research papers available by searching in Pubmed
for Casper RF
- Esfandiari
N, Gotlieb L, Casper R.F. Seminal hyperviscosity is associated
with poor outcome of controlled ovarian stimulation and intrauterine
insemination: A prospective study. Int J Fertil Women¡¯s
Med (in press, January-February issue of 2006)
- Esfandiari
N, Javed M, Gotlieb L, Casper RF. Complete Failed Fertilization
after Intracytoplasmic Sperm Injection - Analysis of 10 Years
Data. Submitted to Int J Fertil Women¡¯s Med 2005,
Jul-Aug;50(4):187-9
- Esfandiari
N, Ryan E, Gotlieb L, Casper RF. Successful pregnancy following
transfer of embryos from oocytes with abnormal zona pellucida
and cytoplasm morphology. Reproductive Biomedicine Online 2005
Vol. 11, No 5, 555-561.
- Esfandiari
N, Gotlieb L, Casper R.F. Live birth of healthy triplets following
in vitro fertilization and embryo transfer in an accromegalic
woman with elevated growth hormone. Fertility Sterility 2005;
83(4), 1041-3.
- Esfandiari
N, Burjaq H, Gotlieb L, Casper R.F. Brown eggs; do they differ
from their white counterparts? Fertility Sterility 2006 (in press).
- Esfandiari
N, Ai J, Khazaei M, Bielecki R, Gotlieb L, Casper R.F. Effect
of a Statin on an In Vitro Model of Endometriosis. (Fertility
Sterility in review).
- Esfandiari
N, Ryan EAJ, Gotlieb L, Casper RF. (2005) Successful pregnancy
following transfer of embryos from oocytes with abnormal zona
pellucida and cytoplasm morphology. Reproductive Biomedicine Online
(in press).
- Esfandiari
N, Gotlieb L, Casper RF (2005). Live birth of healthy triplets
after in vitro fertilization and embryo transfer in an acromegalic
woman with elevated growth hormone. Fert Ster 83(4):1041.
- Mitwally
MF, Biljan MM, Casper RF. (2005) Pregnancy outcome after the use
of an aromatase inhibitor for ovarian stimulation. American Journal
of Obstetrics and Gynecology. 192:381-386.
- Fasciani
A, Bocci G, Xu J, Greenblatt E, Leyland N, Casper RF. (2003) Three-dimensional
in vitro culture of endometrial explants mimics the early stages
of endometriosis. Fertility and Sterility 80(5):1137-1143.
- Mitwally
MF, Casper RF. (2003) Aromatase inhibition reduces gonadotrophin
dose required for controlled ovarian stimulation in women with
unexplained infertility. Human Reproduction 18(8):1588-1597.
- Jurisicova
A, Antenos M, Varmuza S, Tilly J, Casper RF. (2003) Expression
of apoptosis-related genes during human preimplantation embryo
development: Potential roles for the Harakiri gene product and
Caspase-3 in blastomere fragmentation. Mol Hum Reprod, 9(3):133-141.
- Ben
Chetrit A, Antenos M, Jurisicova A, Pasyk E, Chitayat D, Foskett
K, Casper RF. (2002) Expression and function of Cystic fibrosis
transmembrane conductance regulator during early human embryo
development. Mol Hum Reprod 8(8):758-764.
- Mitwally
MF, Gotlieb L, Casper RF. (2002) Prevention of bone loss and hypoestrogenic
symptoms by estrogen and interrupted progestogen addback in long-term
GnRH agonist down-regulated patients with endometriosis and premenstrual
syndrome. Menopause, 9(4):236-241.
- Mitwally
MFM, Casper RF. (2002) Effect of in-vivo GnRH agonist and GnRH
antagonist suppression on progesterone production by human granulosa
lutein cells. Journal of Assisted Reproduction and Genetics 19(8):384-389.
- Revel
A, Raanani H, Younglai E, Xu J, Rogers I, Han R, Savouret J-F,
Casper RF. (2001) Resveratrol, a natural aryl hydrocarbon receptor
antagonist, protects sperm from DNA damage and apoptosis caused
by Benzo(a)pyrene. Reproductive Toxicology, 15(5):479-486.
- Rogers
I, Sutherland DR, Holt D, Macpate F, Lains A, Hollowell S, Cruickshank
B, Casper RF. (2001) Human umbilical cord blood banking: Impact
of blood volume, cell separation and cryopreservation on leukocytes
and CD34+ cell recovery. Cytotherapy 3(4):269-276.
- Zenzes
MT, Bielecki R, Casper RF, Leibo SP. (2001) Effects of chilling
to 0oC on the morphology of meiotic spindles in human metaphase
II oocytes. Fertility and Sterility, 75:769-777.
- Mitwally
MF, Casper RF. (2001) Use of an aromatase inhibitor for induction
of ovulation in cases of inadequate response to clomiphene citrate.
Fertility and Sterility, 75:305-309.
- Weissman
A, Gotlieb L, Ward S, Greenblatt E, Casper RF. (2000) Use of the
internet by infertile couples. Fertil Steril, 73:1179-1182.
- Younglai
EV, Holt D, Brown P, Jurisicova A, Casper RF. (2001) Sperm swimup
techniques and DNA fragmentation. Human Reproduction 16(9):1950-1953.
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